Suter R B, Rawson K S
Science. 1968 May 31;160(3831):1011-4. doi: 10.1126/science.160.3831.1011.
Chemical modification of a vertebrate activity rhythm, the circadian (approximately 24-hour) rhythm of Peromyscus leucopus noveboracensis, has been demonstrated. Activity in a running wheel was used to measure the rhythms of mice kept individually in conditions of continuous darkness. Deuterium oxide was presented in the drinking water. The length of the periods of rhythm increased directly and linearly with the increase in concentration of deuterium oxide. There is no threshold for this effect, and the maximum concentration of deuterium oxide (30 percent) that was presented resulted in a 6 percent lengthening of the period of circadian rhythm. The mice reverted to rhythms similar in period length to control values after deuterium oxide was withdrawn from their drinking water.
已经证明了对脊椎动物活动节律——白足鼠新泽西亚种的昼夜节律（约24小时）进行化学修饰。使用转轮中的活动来测量在持续黑暗条件下单独饲养的小鼠的节律。在饮用水中添加了氧化氘。节律周期的长度随着氧化氘浓度的增加而直接呈线性增加。这种效应没有阈值，所添加的氧化氘的最大浓度（30%）导致昼夜节律周期延长了6%。当从饮用水中去除氧化氘后，小鼠的节律周期长度恢复到与对照值相似的水平。
