Macuch P, Kortus J, Balazova G, Mayer J
Br J Ind Med. 1968 Apr;25(2):131-5. doi: 10.1136/oem.25.2.131.
Rats given 4 mg. fluoride/kg./day for eight days excreted more calcium and phosphorus and retained less than the controls. In bone ash from rats given different fluoride doses for 40 days the calcium and phosphorus were maximal after a total dose of about 250 μg. fluoride/rat, but fell to subnormal levels after higher doses. The calcium and phosphorus levels in bone ash from rats given 750 μg. fluoride/day fell with the duration of treatment. Rats exposed to 9·4-11·7 μg. hydrogen fluoride/litre air absorbed fluoride rapidly, as shown by increased urinary excretion, by changes in the enamel of the teeth, and by rising fluoride levels in the teeth and bones. Radiological examination, however, showed no gross changes. Urinary excretion increased with exposure time.
给大鼠每日每千克体重注射4毫克氟，持续八天，其钙和磷的排泄量比对照组更多，而留存量则更少。给大鼠注射不同剂量的氟，持续40天，当每只大鼠的氟总剂量约为250微克时，骨灰中的钙和磷含量最高，但剂量更高时则降至正常水平以下。每日给大鼠注射750微克氟，骨灰中的钙和磷含量会随着治疗时间的延长而下降。暴露于每升空气中含9.4 - 11.7微克氟化氢环境中的大鼠会迅速吸收氟，这表现为尿排泄增加、牙齿釉质变化以及牙齿和骨骼中氟含量升高。然而，放射学检查未显示明显变化。尿排泄量随暴露时间增加。
