伯氨喹引起的疟疾红细胞外期形态学变化。
Primaquine-induced changes in morphology of exoerythrocytic stages of malaria.
作者信息
Beaudoin R L, Aikawa M
出版信息
Science. 1968 Jun 14;160(3833):1233-4. doi: 10.1126/science.160.3833.1233.
PMID:5648260
Abstract
Exposure to primaquine for 48 hours caused lesions in the exoerythrocytic stages of Plasmodium fallax grown in cultivated cells derived from embryonic turkey brain. The lesions appeared in the form of cytoplasmic vacuoles when viewed under the light microscope. The electron microscope revealed these vacuoles as swollen mitochondria readily identifiable by their typical protozoan cristae. Mitochondria of the host cell were unaffected.
摘要
接触伯氨喹48小时会导致在源自火鸡胚胎脑的培养细胞中生长的法氏疟原虫的红细胞外期出现损伤。在光学显微镜下观察时，损伤表现为细胞质空泡的形式。电子显微镜显示这些空泡是肿胀的线粒体，通过其典型的原生动物嵴很容易识别。宿主细胞的线粒体未受影响。
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