8-氨基喹啉类药物的药理学
Pharmacology of 8-aminoquinolines.
作者信息
Grewal R S
出版信息
Bull World Health Organ. 1981;59(3):397-406.
Abstract
The 8-aminoquinolines were the first group of compounds to be synthesized specifically for their antimalarial activity. A large-scale research programme in the United States of America in the 1940s produced three new antimalarial drugs-pentaquine, isopentaquine, and primaquine -of which primaquine was the most effective. This article reviews knowledge on the activity of these 8-aminoquinolines against all stages of the malaria parasite and suggests their possible modes of action. The toxic effects and possible causal mechanisms are also outlined.
摘要
8-氨基喹啉是首批因其抗疟活性而专门合成的化合物。20世纪40年代在美国开展的一项大规模研究计划研发出了三种新型抗疟药物——喷他喹、异喷他喹和伯氨喹，其中伯氨喹最为有效。本文综述了关于这些8-氨基喹啉对疟原虫各个阶段活性的知识，并提出了它们可能的作用方式。文中还概述了其毒性作用及可能的致病机制。
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