血浆激肽在胰腺功能性血管舒张中的作用。

The role of plasma kinin in functional vasodilatation in the pancreas.

作者信息

Hilton S M, Jones M

出版信息

J Physiol. 1968 Apr;195(3):521-33. doi: 10.1113/jphysiol.1968.sp008472.

DOI:10.1113/jphysiol.1968.sp008472

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1351684/

Abstract

Freshly collected pancreatic juice of the cat contained active kinin-forming enzyme (kallikrein) and, in addition, an active kininase.2. In response to successive doses of secretin, the kinin-forming activity of pancreatic juice fell off considerably. It was restored by pancreozymin.3. Stimulation of the dorsal vagus nerve caused an increase in venous outflow from the pancreas which was greater and more consistently seen when the splanchnic nerves had been sectioned.4. Intravenous injection of highly purified secretin usually had no effect on the outflow, whereas pancreozymin increased it up to 5 times.5. When the pancreas was perfused with oxygenated Locke solution, the effluent contained some kinin-forming enzyme when the gland was at rest. The enzyme activity did not increase when secretin was added to the perfusing fluid, but when acetylcholine or pancreozymin was added, the activity rose about fourfold.6. These results are discussed in relation to the theory that plasma kinins play a prominent role in the functional vasodilatation of glandular tissues.

摘要

刚采集的猫胰液含有活性激肽形成酶（激肽释放酶），此外，还含有一种活性激肽酶。
对连续剂量的促胰液素产生反应时，胰液的激肽形成活性显著下降。它可被促胰酶素恢复。
刺激迷走神经背支会导致胰腺静脉流出量增加，当切断内脏神经时，这种增加更为明显且更持续出现。
静脉注射高度纯化的促胰液素通常对流出量无影响，而促胰酶素可使其增加至5倍。
当用含氧的洛克溶液灌注胰腺时，在腺体静止时流出液中含有一些激肽形成酶。向灌注液中添加促胰液素时酶活性不增加，但添加乙酰胆碱或促胰酶素时，活性升高约四倍。
结合血浆激肽在腺组织功能性血管舒张中起重要作用这一理论对这些结果进行了讨论。