Kharitonova K I, Etiteín Iu V, Slavich V P, Sokolova N M
Vopr Neirokhir. 1978 Jan-Feb(1):35-8.
The storage of dura mater transplants in formalin-containing gel media which allow the entire process of preparation of the biological material to be conducted in non-sterile conditions is substantiated experimentally and clinically. A formalinized allogenous tissue of the same name transplanted in experiments and in the clinic into a defect in the dura mater undergoes active reorganisation and is replaced within a year with a newly-formed connective tissue which does not differ in architectonics from the dura mater of the recipient. When transplants of the dura mater stored in formalin-containing gel media were used in the clinic (172 operations) no complications of the type of liquorrhea, prolapse of the cerebral tissue or coarse subdural adhesions were noted. Suppuration developed in 3 patients (1.7%). The cause of the suppuration, however, was not associated with the transplant. All this makes it possible to recommend allogenous transplants of dura mater stored in formalin-containing gel media for wide use in the practice.
将硬脑膜移植物储存在含福尔马林的凝胶介质中,使得生物材料的整个制备过程能够在非无菌条件下进行,这在实验和临床上都得到了证实。在实验和临床中,将经福尔马林处理的同名同种异体组织移植到硬脑膜缺损处,会经历积极的重组,并在一年内被新形成的结缔组织所替代,该结缔组织在结构上与受体的硬脑膜没有差异。当使用储存在含福尔马林的凝胶介质中的硬脑膜移植物进行临床手术(172例手术)时,未发现脑脊液漏、脑组织脱垂或粗大的硬膜下粘连等并发症。3例患者(1.7%)发生了化脓。然而,化脓的原因与移植物无关。所有这些都使得推荐使用储存在含福尔马林的凝胶介质中的同种异体硬脑膜移植物在临床上广泛应用成为可能。