Nicks R, McGovern V J
Thorax. 1968 Mar;23(2):153-7. doi: 10.1136/thx.23.2.153.
We have examined biopsies of the lingula of the upper lobe of the left lung from 85 patients undergoing mitral valvotomy and have correlated the presence of vascular changes and fibrosis of the lung tissue with pulmonary vascular resistance, the degree and type of mitral stenosis, and the duration of pulmonary symptoms. Factors which significantly affected the prognosis were high pulmonary artery pressures, high vascular resistance, and narrowing of the pulmonary arteries; but, above all, pulmonary fibrosis. The prognosis for patients with mitral incompetence was less favourable than for those without incompetence, especially if there was increased pulmonary vascular resistance and pulmonary hypertension with axis deviation in the electrocardiogram.
我们检查了85例接受二尖瓣切开术患者的左肺上叶舌段活检组织，并将肺组织的血管变化和纤维化情况与肺血管阻力、二尖瓣狭窄的程度和类型以及肺部症状持续时间进行了关联分析。显著影响预后的因素包括肺动脉高压、高血管阻力和肺动脉狭窄；但最重要的是肺纤维化。二尖瓣关闭不全患者的预后比无关闭不全者更差，尤其是当存在肺血管阻力增加、肺动脉高压且心电图有轴偏移时。
