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The central action of 1-p-dimethylaminophenyl-5-allyl-5-(beta-hydroxypropyl) barbituric acid and the corresponding lactone.

作者信息

Hano J, Sypniewska M, Chojnacka-Wójcik E

出版信息

Pol J Pharmacol Pharm. 1978 Jan-Feb;30(1):55-61.

PMID:565512
Abstract

1-p-dimethylaminophenyl-5-allyl-5-(beta-hydroxypropyl)barbituric acid (NP) and the probably product of its isomerization alpha-(p-dimethylaminophenyl)allophanyl-alpha-allyl-gamma-methylbutyrolactone (MW) was studied. Behavioral experiments carried out on mice and rats showed that both the acid (NP) and the lactone (MW) suppress the reactivity of the central nervous system, and, to some degree, act like tranquilizing agents.

摘要

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