关于乳腺癌、利血平问题的一种实验方法。

An experimental approach to the breast cancer, reserpine problem.

作者信息

Homburger F, van Dongen C G, Adams R A, Soto E A, Pai K J

出版信息

Cancer Lett. 1978 Mar;4(3):177-83. doi: 10.1016/s0304-3835(78)94292-1.

Abstract

Reserpine was administered intraperitoneally 3 times weekly to inbred female Syrian BIO hamsters of the 15.16 strain previously shown to be susceptible to methylcholanthrene (MC) induction of mammary cancer. Other groups of hamsters received non-carcinogenic doses of MC along with the reserpine administrations, and an additional group received a carcinogenic dose of MC alone. This last group demonstrated that BIO 15.6 females were indeed susceptible to MC mammary cancer induction, since 4 mg of MC administered by stomach tube (a total dose of 200 mg) caused mammary cancer in 52% of the animals. Mammary cancer was not observed in any of the animals given reserpine or reserpine in combination with the non-carcinogenic dose of MC.

摘要

对先前已证明易受甲基胆蒽（MC）诱导患乳腺癌的15.16品系近交雌性叙利亚BIO仓鼠，每周3次腹腔注射利血平。其他几组仓鼠在给予利血平的同时接受非致癌剂量的MC，另外一组仅接受致癌剂量的MC。最后一组表明，BIO 15.6雌性仓鼠确实易受MC诱导患乳腺癌，因为经胃管给予4mg MC（总剂量200mg）使52%的动物患乳腺癌。在给予利血平或利血平与非致癌剂量MC组合的任何动物中均未观察到乳腺癌。