4-亮氨酸-催产素：利钠、利尿及抗血管升压素多肽。
4-Leucine-oxytocin: natriuretic, diuretic, and antivasopressin polypeptide.
作者信息
Chan W Y, Hruby V J, Flouret G, Du Vigneuad V
出版信息
Science. 1968 Jul 19;161(3838):280-1. doi: 10.1126/science.161.3838.280.
PMID:5657333
Abstract
During water diuresis in anesthetized rats, 4-leucine-oxytocin increased the urine output and the rates of sodium and chloride excretion. The potassium excretion rate was only slightly increased. During vasopressin-suppressed water diuresis, 4-leucine-oxytocin produced similar effects on urine and electrolyte excretions. In addition, it inhibited the vasopressin-induced free-water reabsorption, and it could reverse reabsorption to freewater clearance.
摘要
在麻醉大鼠的水利尿过程中，4-亮氨酸-催产素增加了尿量以及钠和氯的排泄率。钾排泄率仅略有增加。在血管升压素抑制的水利尿过程中，4-亮氨酸-催产素对尿液和电解质排泄产生了类似的影响。此外，它抑制了血管升压素诱导的自由水重吸收，并能使重吸收转变为自由水清除率。
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