消胆胺对一名高胆固醇血症患者静脉注射胆固醇-4-¹⁴C及其降解产物粪便排泄的影响。
Effect of cholestyramine on the fecal excretion of intravenously administered cholesterol-4-14C and its degradation products in a hypercholesterolemic patient.
作者信息
Moore R B, Crane C A, Frantz I D
出版信息
J Clin Invest. 1968 Jul;47(7):1664-71. doi: 10.1172/JCI105857.
Abstract
The effect of cholestyramine on the fecal excretion of bile acids and neutral sterols was measured in a hypercholesterolemic patient on a low fat, high polyunsaturated fatty acid-containing diet after the intravenous injection of cholesterol-4-(14)C. A significant (16%) lowering of serum cholesterol concentration was accompanied by a 3.2-fold increase in fecal bile acid excretion but no change in neutral sterol output. The increased bile acid loss was adequate to account for the observed fall in serum cholesterol level. The implications of these findings were discussed.
摘要
在一名高胆固醇血症患者摄入低脂、富含高多不饱和脂肪酸的饮食后，静脉注射胆固醇-4-(14)C，测定了消胆胺对胆汁酸和中性固醇粪便排泄的影响。血清胆固醇浓度显著降低（16%），同时粪便胆汁酸排泄增加了3.2倍，但中性固醇排出量没有变化。胆汁酸损失的增加足以解释观察到的血清胆固醇水平下降。讨论了这些发现的意义。
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