Hewson J R
Anesth Analg. 1978 May-Jun;57(3):298-302. doi: 10.1213/00000539-197805000-00003.
In 11 elective coronary artery bypass graft (CABG) recipients, changes in alveolar-arterial O2 tension difference (deltaAaDO2) from 5 minutes before to 30 minutes after cardiopulmonary bypass (CPB) ranged from -54.9 to +63.1 torr and exhibited significant linear correlation (r = 0.77, p less than 0.01) with the mean arterial perfusion pressure (MAPP) during CPB multiplied by the duration (T) of CPB divided by the body surface area (BSA) of the patient. The regression equation (deltaAaDO2 = 0.015 MAPP divided by BSA X T -50) enables estimation of the delta AaDO2 to result from a given episode of CPB. Mural edema of airways and pulmonary vasculature, developing during CPB, may be a mechanism underlying this correlation.
在11例择期冠状动脉旁路移植术（CABG）受者中，体外循环（CPB）前5分钟至CPB后30分钟期间，肺泡 - 动脉氧分压差（deltaAaDO2）的变化范围为 -54.9至 +63.1托，并且与CPB期间的平均动脉灌注压（MAPP）乘以CPB持续时间（T）除以患者体表面积（BSA）呈显著线性相关（r = 0.77，p <0.01）。回归方程（deltaAaDO2 = 0.015×MAPP / BSA×T - 50）能够根据给定的CPB过程估算delta AaDO2。CPB期间发生的气道和肺血管壁水肿可能是这种相关性的潜在机制。
