人血清中脱氧核糖核酸酶抑制剂水平与抗核抗体出现的关系。
The relationship of desoxyribonuclease inhibitor levels in human sera to the occurrence of antinuclear antibodies.
作者信息
Frost P G, Lachmann P J
出版信息
Clin Exp Immunol. 1968 Jun;3(5):447-55.
Abstract
A group of sera from hospital patients and normal subjects has been tested for the presence of antinuclear antibodies, and the amount of labile inhibitor to desoxyribonuclease 1 present in each of the sera estimated. It has been found that the presence of antinuclear antibodies is associated with a high level of inhibitor to a statistically significant degree. It has also been found that this inhibitor is formed during the clotting of whole blood and that it is derived from platelets. A possible relationship between the inhibitor, its formation during the clotting of blood, and the characteristic presence of antinuclear antibodies in systemic lupus erythematosus is discussed.
摘要
对一组来自医院患者和正常受试者的血清进行了抗核抗体检测，并估算了每份血清中脱氧核糖核酸酶1不稳定抑制剂的含量。结果发现，抗核抗体的存在与高水平的抑制剂在统计学上具有显著相关性。还发现这种抑制剂是在全血凝固过程中形成的，并且它来源于血小板。文中讨论了该抑制剂、其在血液凝固过程中的形成以及系统性红斑狼疮中抗核抗体特征性存在之间的可能关系。
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