Hill P M, Shaw K M
Thorax. 1968 Jul;23(4):408-13. doi: 10.1136/thx.23.4.408.
Sixteen dogs which survived left pulmonary reimplantation were subjected to staged contralateral pneumonectomy. Complete excision of the right lung was achieved in nine of these animals. There were three long-term survivors, of which two lived for more than three years on the single reimplanted lung. Stenosis of the pulmonary veins at the level of the atrial anastomosis was the commonest post-mortem finding. In the first week after reimplantation, the ventilation and oxygen uptake of the reimplanted lung invariably fell to low levels. These usually rose slowly but to a variable extent over the next six to eight weeks, after which there was little further improvement while the normal lung remained intact. In all three long-term survivors the ventilation and oxygen uptake of the reimplanted lung were more than doubled after contralateral pneumonectomy; the rise in oxygen uptake was less and occurred later than the rise in ventilation. Pulmonary hypertension and pulmonary oedema did not occur except in association with organic obstruction to the pulmonary venous drainage.
16只存活的左肺再植犬接受了分期对侧肺切除术。其中9只动物成功完成了右肺的完全切除。有3只长期存活者，其中2只依靠单肺再植存活了三年多。肺静脉在心房吻合水平处狭窄是最常见的尸检发现。再植后的第一周，再植肺的通气和氧摄取量总是降至低水平。在接下来的6至8周内，这些指标通常会缓慢上升，但程度不一，此后在正常肺保持完整的情况下几乎没有进一步改善。在所有3只长期存活者中，对侧肺切除术后，再植肺的通气和氧摄取量增加了一倍多；氧摄取量的增加幅度较小，且比通气量的增加出现得更晚。除了与肺静脉引流的器质性梗阻相关外，未发生肺动脉高压和肺水肿。
