Zsolnai T
Zentralbl Bakteriol Orig A. 1978 Apr;240(3):380-4.
The author produced a number of aryl-hydrazones of mesoxalic-acid-seminitril-hydrazide and their N2-acyl-derivatives, farther the halogeno-substituted phenyl-hydrazones of mesoxalic-acid-seminitril-hydrazones, and investigated their fungistatic efficiency in vitro. From the author's results it can be concluded, that 2-, 3- and 4-chloro-phenyl-hydrazones of mesoxalic-acid-siminitril-hydrazide exert a strong fungistatic effect on Trichophyton- and Epidermophyton-species, but they are inactive on other fungi-strains. Their N2-acyl-derivatives, farther with aldehydes and ketones formed derivatives of the previous compounds exert any fungistatic effect neither on Trichophyton- and Epidermophyton-species, nor on other fungi-strains. From this it can be concluded, that the fungistatic activity of the investigated compounds is strong structur-specific.
作者制备了一系列中草酸半腈酰肼的芳基腙及其N2-酰基衍生物，还制备了中草酸半腈腙的卤代苯基腙，并研究了它们的体外抑菌效率。从作者的结果可以得出结论，中草酸半腈酰肼的2-、3-和4-氯苯基腙对毛癣菌属和表皮癣菌属物种具有很强的抑菌作用，但对其他真菌菌株无活性。它们的N2-酰基衍生物，以及与醛和酮形成的前一种化合物的衍生物，对毛癣菌属和表皮癣菌属物种以及其他真菌菌株均无抑菌作用。由此可以得出结论，所研究化合物的抑菌活性具有很强的结构特异性。
