一名高血压新生儿尿液中1-氧化类固醇的部分特征分析
The partial characterization of 1-oxygenated steroids from urine of a hypertensive newborn child.
作者信息
Edwards R W, Trafford D J
出版信息
Biochem J. 1968 Jun;108(2):185-93. doi: 10.1042/bj1080185.
Abstract
- Four substances from the urine of a hypertensive newborn girl were partially characterized and shown to be 17alpha-hydroxy-5beta-pregnane-1,3,20-trione, 3alpha,17alpha-dihydroxy-5beta-pregnane-1,20-dione, 3alpha,17alpha,20alpha-trihydroxy-5beta-pregnan-1-one and 5beta-pregnane-1beta,3alpha,17alpha,20alpha-tetrol. 2. The characterization rested mainly on R(M) analysis of the substances and their derivatives by glycol fission, providing evidence for position and degree of substitution and for steroidal character. Supporting evidence was provided by chemically specific location reactions. 3. Certain problems in the manipulation of these beta-disubstituted steroids are discussed.
摘要
- 对一名患高血压的新生女婴尿液中的四种物质进行了部分特性鉴定，结果表明它们分别是17α-羟基-5β-孕烷-1,3,20-三酮、3α,17α-二羟基-5β-孕烷-1,20-二酮、3α,17α,20α-三羟基-5β-孕烷-1-酮和5β-孕烷-1β,3α,17α,20α-四醇。2. 特性鉴定主要基于通过二醇裂解对这些物质及其衍生物进行的R(M)分析，为取代位置和程度以及甾体特性提供了证据。化学特异性定位反应提供了支持证据。3. 讨论了这些β-二取代甾体操作过程中的某些问题。
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