The effect of infusions of plasma and of saline on the renal response to water-loading in sodium-depleted dogs.

1. Infusion of 150 ml. of plasma to dogs acutely depleted of sodium chloride by peritoneal dialysis with glucose (5 g/100 ml.) does not restore their ability to respond by diuresis when given 2.5% body weight of water by mouth.2. Infusion of 300 ml. of saline (0.73g NaCl/100 ml.) to these animals results in a brisk increase in urinary flow.3. Infusion of 100 ml. of saline (0.73g NaCl/100 ml.) to sodium-depleted dogs restores their ability to respond to a water-load of 2.5% of body weight by diuresis.4. The results are discussed and a tentative explanation put forward.