治疗持续时间对大鼠巴比妥类药物戒断期间听源性惊厥易感性的影响。
Influence of treatment duration on audiogenic seizure susceptibility during barbiturate withdrawal in rats.
作者信息
McGee D H, Bourn W M
出版信息
Experientia. 1978 Jul 15;34(7):873-4. doi: 10.1007/BF01939675.
PMID:566673
Abstract
Barbiturate withdrawal seizure susceptibility in rats increased with increasing duration of treatment during a 15-day treatment period in which the animals were given an i.p. dose of sodium barbital every 12 h. This method of producing dependence has clear advantages over previously described methods.
摘要
在为期15天的治疗期内，大鼠每隔12小时腹腔注射一次巴比妥钠，随着治疗时间的延长，大鼠对巴比妥类药物戒断性癫痫的易感性增加。这种产生依赖性的方法比先前描述的方法具有明显优势。
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