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异染性脑白质营养不良：通过静脉血样本进行诊断

Metachromatic leukodystrophy: diagnosis with samples of venous blood.

作者信息

Percy A K, Brady R O

出版信息

Science. 1968 Aug 9;161(3841):594-5. doi: 10.1126/science.161.3841.594.

DOI:10.1126/science.161.3841.594
PMID:5668537
Abstract

Arylsulfatase A and B have been demonstrated in preparations of human leukocytes. The level of activity of arylsulfatase A is markedly decreased in the preparations from patients with metachromatic leukodystrophy. Acid phosphatase and arylsulfatase B activities were normal. The assay of arylsulfatase A in leukocyte preparations can be useful in the diagnosis of metachromatic leukodystrophy while obviating the difficulties of current methods.

摘要

已在人白细胞制剂中证实了芳基硫酸酯酶A和B。在异染性脑白质营养不良患者的制剂中，芳基硫酸酯酶A的活性水平显著降低。酸性磷酸酶和芳基硫酸酯酶B的活性正常。白细胞制剂中芳基硫酸酯酶A的检测在异染性脑白质营养不良的诊断中可能有用，同时避免了现有方法的困难。

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Metachromatic leukodystrophy: diagnosis with samples of venous blood.异染性脑白质营养不良：通过静脉血样本进行诊断
Science. 1968 Aug 9;161(3841):594-5. doi: 10.1126/science.161.3841.594.
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[Diagnostic value of the determination of intraleukocytic arylsulfatase for the early detection of metachromatic leukodystrophy].白细胞内芳基硫酸酯酶测定对异染性脑白质营养不良早期检测的诊断价值
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The use of white cells as a source of diagnostic material for lipid storage diseases.将白细胞用作脂质贮积病诊断材料的来源。
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