Chandraratna P A, Chu W, Schechter E, Langevin E
Chest. 1978 Aug;74(2):183-9. doi: 10.1378/chest.74.2.183.
In ten normal subjects, we observed an initial hump in the aortic root echocardiogram after the onset of the QRS complex, following which a sharp anterior motion was noted. The onset of the anterior motion of the aortic root coincided with the onset of the upstroke of the aortic root pressure pulse and the onset of the velocity signal in five of seven patients with coronary arterial disease; in the other two, the anterior aortic motion followed the onset of the pressure and velocity signal by 10 msec. The aortic root echocardiogram was abnormal in patients with idiopathic hypertrophic subaortic stenosis; the slope (normalized for the scales of time and depth) in early systole was steeper and in the latter part of systole was flatter than normal in these patients. The slope in early diastole was flatter and the slope due to atrial contraction was steeper in the patients with idiopathic hypertrophic subaortic stenosis than in the normal subjects. These features were consistent with rapid ejection in early systole and slow filling in the early phase of ventricular diastole in idiopathic hypertrophic subaortic stenosis. Fourier analysis of the wave form of the aortic root allowed separation between patients with idiopathic hypertrophic subaortic stenosis and normal subjects.
在10名正常受试者中，我们观察到在QRS波群开始后，主动脉根部超声心动图出现一个初始波峰，随后出现明显的向前运动。在7例冠状动脉疾病患者中，有5例主动脉根部向前运动的开始与主动脉根部压力脉冲上升支的开始以及速度信号的开始同时出现；在另外2例中，主动脉根部向前运动在压力和速度信号开始后10毫秒出现。特发性肥厚性主动脉瓣下狭窄患者的主动脉根部超声心动图异常；在这些患者中，收缩早期的斜率（按时间和深度比例归一化）比正常情况更陡，而在收缩后期则比正常情况更平缓。特发性肥厚性主动脉瓣下狭窄患者舒张早期的斜率比正常受试者更平缓，而心房收缩引起的斜率更陡。这些特征与特发性肥厚性主动脉瓣下狭窄患者收缩早期快速射血和心室舒张早期缓慢充盈一致。对主动脉根部波形进行傅里叶分析可以区分特发性肥厚性主动脉瓣下狭窄患者和正常受试者。
