己烯雌酚衍生物对脱氧核糖核酸核苷酸转移酶的抑制作用。
The inhibition of deoxyribonucleic acid nucleotidyltransferase by stilboestrol derivatives.
作者信息
Fahmy A R, Griffiths K
出版信息
Biochem J. 1968 Aug;108(5):749-53. doi: 10.1042/bj1080749.
Abstract
The inhibition by diethylstilboestrol of DNA nucleotidyltransferase isolated from calf thymus was studied. The inhibition exercised by diethylstilboestrol appears to obey competitive kinetics with respect to DNA primer. The activities of both replicative and terminal enzymes were affected to the same extent. There was no evidence of binding between DNA and diethylstilboestrol. A comparative study of the inhibitory effects of some stilboestrol derivatives is presented. The alkyl substitution in the alphaalpha'-positions seem to alter the inhibitory effect of these compounds: dimethylstilboestrol was more inhibitory than stilbene, and diethylstilboestrol was more inhibitory than dimethylstilboestrol. Hexoestrol, in which the alphaalpha'-ethylenic linkage is saturated, was the most effective inhibitor.
摘要
研究了己烯雌酚对从小牛胸腺分离的DNA核苷酸转移酶的抑制作用。己烯雌酚所产生的抑制作用似乎遵循关于DNA引物的竞争性动力学。复制酶和末端酶的活性受到同等程度的影响。没有证据表明DNA与己烯雌酚之间存在结合。本文对一些己烯雌酚衍生物的抑制作用进行了比较研究。αα′位的烷基取代似乎改变了这些化合物的抑制作用：二甲基己烯雌酚比芪的抑制作用更强，而己烯雌酚比二甲基己烯雌酚的抑制作用更强。αα′位烯键饱和的己烷雌酚是最有效的抑制剂。
相似文献
1
The inhibition of deoxyribonucleic acid nucleotidyltransferase by stilboestrol derivatives.己烯雌酚衍生物对脱氧核糖核酸核苷酸转移酶的抑制作用。
Biochem J. 1968 Aug;108(5):749-53. doi: 10.1042/bj1080749.
2
Isolation of a terminal DNA-nucleotidyl transferase from calf thymus non-histone chromatin proteins.从小牛胸腺非组蛋白染色质蛋白中分离出一种末端DNA核苷酸转移酶。
Arch Biochem Biophys. 1968 Sep 20;127(1):235-40. doi: 10.1016/0003-9861(68)90221-x.
3
Inhibiton of calf thymus deoxyribonucleic acid polymerase by histones.组蛋白对小牛胸腺脱氧核糖核酸聚合酶的抑制作用。
Biochemistry. 1968 Jun;7(6):2256-63. doi: 10.1021/bi00846a031.
4
5
Enzymatic synthesis of deoxyribonucleic acid. XXXIV. Termination of chain growth by a 2',3'-dideoxyribonucleotide.脱氧核糖核酸的酶促合成。三十四。2',3'-二脱氧核糖核苷酸对链生长的终止作用。
Biochemistry. 1969 Dec;8(12):4897-904. doi: 10.1021/bi00840a037.
6
Effect of cytosine arabinoside 5'-triphosphate on mammalian DNA polymerase.5'-三磷酸阿糖胞苷对哺乳动物DNA聚合酶的作用。
Biochem Biophys Res Commun. 1969 Feb 21;34(4):464-71. doi: 10.1016/0006-291x(69)90405-7.
7
8
Inhibition of deoxyribonucleic acid polymerases alpha and beta and terminal deoxynucleotidyl transferase from calf thymus by mitomycin C-deoxyribonucleic acid.丝裂霉素C-脱氧核糖核酸对小牛胸腺脱氧核糖核酸聚合酶α和β以及末端脱氧核苷酸转移酶的抑制作用。
Biochem Pharmacol. 1981 Feb 15;30(4):299-303. doi: 10.1016/0006-2952(81)90058-7.
9
The structural specificity involved in the inhibition of a microbial D-glucose-6-phosphate dehydrogenase by synthetic estrogens.合成雌激素对微生物D-葡萄糖-6-磷酸脱氢酶抑制作用所涉及的结构特异性。
Biochim Biophys Acta. 1966 May 26;121(1):90-101. doi: 10.1016/0304-4165(66)90351-5.
10
A factor from calf thymus stimulating DNA-dependent RNA polymerase isolated from this tissue.一种来自小牛胸腺的因子，可刺激从该组织中分离出的依赖DNA的RNA聚合酶。
Eur J Biochem. 1970 Jun;14(2):270-7. doi: 10.1111/j.1432-1033.1970.tb00286.x.
引用本文的文献
1
Short-term and long-term effects of estrogen on lymphoid tissues and lymphoid cells with some remarks on the significance for carcinogenesis.雌激素对淋巴组织和淋巴细胞的短期及长期影响，并对其在致癌作用中的意义作一些阐述。
Arch Toxicol. 1984 Jul;55(2):79-90. doi: 10.1007/BF00346044.
2
The effect of prostatic metabolites of testosterone and other substances on the isolated deoxyribonucleic acid polymerase of the canine prostate.睾酮及其他物质的前列腺代谢产物对犬前列腺分离的脱氧核糖核酸聚合酶的影响。
Biochem J. 1970 Oct;119(4):785-6. doi: 10.1042/bj1190785.
3
Studies on steroid fever. II. Pyrogenic and anti-pyrogenic activity in vitro of some endogenous steroids of man.类固醇热的研究。II. 人体某些内源性类固醇的体外致热和抗热活性
J Clin Invest. 1970 Dec;49(12):2418-26. doi: 10.1172/JCI106461.
4
The effect of some stilboestrol compounds on deoxyribonucleic acid polymerase from human and canine prostatic tissue.某些己烯雌酚化合物对人和犬前列腺组织中脱氧核糖核酸聚合酶的影响。
Biochem J. 1969 Oct;114(4):58P-59P. doi: 10.1042/bj1140058pb.
5
Relation of 8-ketotrichothecene and zearalenone analog structure to inhibition of mitogen-induced human lymphocyte blastogenesis.8-酮单端孢霉烯族毒素和玉米赤霉烯酮类似物结构与有丝分裂原诱导的人淋巴细胞增殖抑制的关系。
Appl Environ Microbiol. 1985 Nov;50(5):1304-7. doi: 10.1128/aem.50.5.1304-1307.1985.
本文引用的文献
1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
THE EFFECT OF DIETHYLSTILBOESTROL ON TESTICULAR 17ALPHA-HYDROXYLASE AND 17-DESMOLASE ACTIVITIES IN BALB/C MICE.己烯雌酚对BALB/C小鼠睾丸17α-羟化酶和17-碳链裂解酶活性的影响
Acta Endocrinol (Copenh). 1964 Apr;45:487-97. doi: 10.1530/acta.0.0450487.
3
INHIBITION OF A MAMMALIAN DEOXYRIBONUCLEIC ACID NUCLEOTIDYLTRANSFERASE BY ACTINOMYCIN D.放线菌素D对哺乳动物脱氧核糖核酸核苷酸转移酶的抑制作用
Biochem J. 1963 Dec;89(3):425-30. doi: 10.1042/bj0890425.
4
Characteristics of the DNA nucleotidyltransferase activity in non-aqueous type calf-thymus nuclei.非水相小牛胸腺细胞核中DNA核苷酸转移酶活性的特性
Biochim Biophys Acta. 1963 Apr 30;68:589-98. doi: 10.1016/0006-3002(63)90188-4.
5
Localization of the biochemical site of action of testosterone on protein synthesis in the seminal vesicle of the rat.睾酮对大鼠精囊蛋白质合成作用的生化位点定位
J Clin Invest. 1962 Jan;41(1):153-61. doi: 10.1172/JCI104458.
6
Effects of estrogen and HCG on androgen synthesis by human testes.雌激素和人绒毛膜促性腺激素对人睾丸雄激素合成的影响。
J Clin Endocrinol Metab. 1962 Oct;22:992-5. doi: 10.1210/jcem-22-10-992.
7
Structure-activity correlations of actinomycins and their derivatives.放线菌素及其衍生物的构效关系。
Nature. 1962 Nov 24;196:743-8. doi: 10.1038/196743a0.
8
Basis of actinomycin action. I. DNA binding and inhibition of RNA-polymerase synthetic reactions by actinomycin.放线菌素的作用基础。I. 放线菌素与DNA的结合及对RNA聚合酶合成反应的抑制
Proc Natl Acad Sci U S A. 1962 Dec 15;48(12):2094-101. doi: 10.1073/pnas.48.12.2094.
9
An effect of testosterone on amino acid incorporation by prostatic ribonucleoprotein particles.睾酮对前列腺核糖核蛋白颗粒氨基酸掺入的影响。
Proc Natl Acad Sci U S A. 1962 Nov 15;48(11):1956-64. doi: 10.1073/pnas.48.11.1956.
10
Studies with tritium-labelled hexoestrol in advanced breast cancer. Comparison of tissue accumulation of hexoestrol with response to bilateral adrenalectomy and oophorectomy.氚标记己烷雌酚在晚期乳腺癌中的研究。己烷雌酚的组织蓄积与双侧肾上腺切除术和卵巢切除术反应的比较。
Lancet. 1961 Oct 7;2(7206):796-8. doi: 10.1016/s0140-6736(61)91088-1.
Zotero 插件