Kumar V, Mortelmans J
Parasitology. 1976 Feb;72(1):13-8. doi: 10.1017/s0031182000043146.
The effect of chemical abbreviation of the primary infection dose (PID) of 160 infective larvae of Metastrongylus apri on the immune status of the guinea-pig host was studied. The criteria used for assessing the status of immunity consisted of clinical manifestations following administration of a challenge infection dose (CID) of 800 infective larvae of M. apri, the rate of worm recovery 15 days post-CID and the rate of mortality following administration of CID. Among the guinea-pigs of the main experimental group, where 15-day-old PID was abbreviated by two parenteral doses of levamisole, a strong immunity to CID given 35 days post-PID was built-up. Against this, all the guinea-pigs of a control group, which did not receive PID, died between 16 and 22 days post-CID. The increase in serum gamma-globulin level of the guinea-pigs, where the PID was abbreviated chemically, suggested that the rise of this globulin fraction in the serum could be in some way related to the resistant state of guinea-pigs.
研究了将160条猪后圆线虫感染性幼虫的初次感染剂量（PID）进行化学缩短对豚鼠宿主免疫状态的影响。用于评估免疫状态的标准包括在给予800条猪后圆线虫感染性幼虫的攻击感染剂量（CID）后出现的临床表现、CID后15天的蠕虫回收率以及给予CID后的死亡率。在主要实验组的豚鼠中，通过两次肌肉注射左旋咪唑缩短15日龄的PID，在PID后35天给予CID时建立了对其的强大免疫力。与此相反，未接受PID的对照组所有豚鼠在CID后16至22天之间死亡。化学缩短PID的豚鼠血清γ-球蛋白水平升高，表明血清中该球蛋白部分的升高可能在某种程度上与豚鼠的抗性状态有关。
