[Changes in neurons of a spinal ganglion culture during chronic exposure to increasing concentrations of morphine].

On the model of spinal ganglion cultures in mice by means of a light and electron microscopy the authors studied neuron changes in chronic influence of increasing concentrations of morphine. These studies demonstrated changes in most of the cytoplasmatic organells: changes in the granular and agranular reticulum; an appearance of a large amount of small vesicles in the cytoplasma and lysosome; changes of the mitochondria (partial vacuolization of the crysts and appearance of a big amount of small mitochondria); a large amount of myelin-like structures; changes of the nuclear membranes; nucleoli and an increased amount of ribosomes.