Stefanini M, Hoffman M N
Am J Med Sci. 1978 May-Jun;275(3):365-71. doi: 10.1097/00000441-197805000-00015.
A patient developed severe thrombocytopenia three days after the administration of lidocaine (Xylocaine) for dental extractions. Petechial bleeding and thrombocytopenia regressed promptly, probably aided by treatment with adrenocorticotropic hormone (ACTH) and prednisone. The patient is well one year after her experience and has received other drugs with impunity. The thrombocytopenia appeared related to the presence of a specific antibody, predominantly immunoglobulin M (IgM), heat labile, in the patient's plasma and serum. The antibody was lytic in action and needed complement. It probably coupled to the drug, forming an antigen-antibody complex able to fix itself to and cause the lysis of platelets. Thrombocytopenia was induced with the parenteral administration of a small dose of lidocaine to the patient. This case may represent the first recorded example of hematologic complication related to the use of lidocaine.
一名患者在接受利多卡因（赛罗卡因）进行拔牙治疗三天后出现严重血小板减少症。瘀点出血和血小板减少症迅速消退，这可能得益于促肾上腺皮质激素（ACTH）和泼尼松的治疗。该患者在经历此事一年后情况良好，且使用其他药物也未出现问题。血小板减少症似乎与患者血浆和血清中存在一种特定抗体有关，该抗体主要为免疫球蛋白M（IgM），对热不稳定。该抗体具有溶细胞作用，且需要补体。它可能与药物结合，形成一种抗原 - 抗体复合物，能够附着于血小板并导致其溶解。对该患者静脉注射小剂量利多卡因可诱发血小板减少症。此病例可能是与使用利多卡因相关的血液学并发症的首例记录案例。
