酪胺对兔耳动脉的作用。

The action of tyramine on the rabbit ear artery.

作者信息

De la Lande I S, Waterson J G

出版信息

Br J Pharmacol. 1968 Sep;34(1):8-18. doi: 10.1111/j.1476-5381.1968.tb07944.x.

DOI:10.1111/j.1476-5381.1968.tb07944.x

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1703442/

Abstract

The vasoconstrictor potency of extraluminal tyramine on the isolated perfused rabbit ear artery is considerably greater than that of intraluminal tyramine.2. Chronic denervation, which caused the noradrenergic storage structures in the medial-adventitial border of the artery to disappear, reduces the potency of extraluminal tyramine more than that of intraluminal tyramine so that the difference in potency for the two routes of administration tends to disappear. Cocaine exerts a greater inhibitory effect on responses to extraluminal tyramine than on those to intraluminal tyramine.3. It is concluded that the indirect component plays a more prominent part in the responses to extraluminal tyramine than in those to intraluminal tyramine. This conclusion is supported by analysis of the diphasic response of the artery to intraluminal injection of tyramine under perfusion conditions which permit intraluminal fluid to mix with the extraluminal fluid. Evidence is presented that the first phase of the response is mediated by intraluminal tyramine, and the second phase by extraluminal tyramine.

摘要

管外酪胺对离体灌注兔耳动脉的血管收缩效力明显大于管内酪胺。
慢性去神经支配使动脉中膜 - 外膜边界处的去甲肾上腺素能储存结构消失，降低管外酪胺效力的程度大于管内酪胺，使得两种给药途径效力的差异趋于消失。可卡因对管外酪胺反应的抑制作用比对管内酪胺反应的抑制作用更强。
得出的结论是，间接成分在对管外酪胺的反应中比在对管内酪胺的反应中起更突出的作用。在允许管内液体与管外液体混合的灌注条件下，对动脉对管内注射酪胺的双相反应进行分析，支持了这一结论。有证据表明，反应的第一阶段由管内酪胺介导，第二阶段由管外酪胺介导。