Rigas A N, Bittles A H, Hadden D R, Montgomery D A
Br Med J. 1968 Oct 5;4(5622):25-8.
The circadian rhythms of preprandial and postprandial blood glucose, free fatty acids, and insulin levels were measured in groups of normal and of diabetic patients controlled by diet alone or by diet with tolbutamide, chlorpropamide, or metformin. All groups showed a greater insulin release after the first meal of the day than after subsequent meals. Diabetic patients controlled for more than two years on diguanide therapy showed the closest resemblance to non-diabetic control subjects. There was no significant difference between the values for diabetic patients on long-term control with diet alone and those on short- or long-acting sulphonylurea. The circadian rhythms disappeared in obese subjects on total starvation.
对仅通过饮食控制或通过饮食加甲苯磺丁脲、氯磺丙脲或二甲双胍控制的正常患者组和糖尿病患者组，测量了餐前和餐后血糖、游离脂肪酸及胰岛素水平的昼夜节律。所有组在一天中的第一餐后比随后的餐次后胰岛素释放更多。接受双胍类治疗超过两年的糖尿病患者与非糖尿病对照受试者最为相似。仅通过饮食长期控制的糖尿病患者与使用短效或长效磺脲类药物的患者的值之间无显著差异。完全饥饿的肥胖受试者的昼夜节律消失。
