Cranford R E, Leppik I E, Patrick B, Anderson C B, Kostick B
Neurology. 1978 Sep;28(9 Pt 1):874-80. doi: 10.1212/wnl.28.9.874.
Phenytoin was administered intravenously in large doses (mean = 16.6 mg per kilogram) for prevention and treatment of seizures on 159 occasions to 139 patients aged 17 to 94 years (mean = 52 years) and weighing 37 to 113 kg (mean = 65 kg). Hypotension was more frequent among older patients. No deaths were attributable to phenytoin. Volumes of distribution were relatively constant (mean = 0.78 +/- 0.11 liters per kilogram), but half-lives varied considerably and were prolonged (mean = 51 +/- 32 hours) because of the large doses administered. A dose of 18 mg per kilogram was effective in maintaining phenytoin serum levels above 10 microgram per milliliter for 24 hours.
对139名年龄在17至94岁（平均52岁）、体重37至113千克（平均65千克）的患者，共159次静脉注射大剂量（平均每千克16.6毫克）苯妥英钠以预防和治疗癫痫发作。老年患者中低血压更为常见。无死亡病例归因于苯妥英钠。分布容积相对恒定（平均每千克0.78±0.11升），但由于给药剂量大，半衰期差异很大且延长（平均51±32小时）。每千克18毫克的剂量可有效维持苯妥英钠血清水平在每毫升10微克以上达24小时。
