Genetically determined sex-reversal in 46,XY humans.
作者信息
German J, Simpson J L, Chaganti R S, Summitt R L, Reid L B, Merkatz I R
出版信息
Science. 1978 Oct 6;202(4363):53-6. doi: 10.1126/science.567843.
PMID:567843
Abstract
Evidence is presented for the existence of a gene, probably on the X chromosome, which prevents testis differentiation when present in 46,XY human embryos. Affected 46,XY women are not completely normal because of premature ovarian involution, as a result of which they have "streak gonads" similiar to those of 45,X women.
摘要
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