Walker B E, Kelleher J
J Nutr. 1978 Oct;108(10):1702-7. doi: 10.1093/jn/108.10.1702.
Serial measurements of plasma, whole blood, and urine zinc have been made in young adult rats fed zinc deficient and zinc supplemented diets for a total period of 65 days. After commencing a zinc deficient diet plasma zinc fell within 48 hours to 25% of control values and remained at this level throughout the period of study. A substantial diurnal variation was observed in plasma zinc, and the level was significantly lower in the fasting state. Whole blood zinc was unaffected by fasting, showed no diurnal variation, and remained at control values even after 65 days of zinc deficient diet. Urine zinc fell to very low values, 10 days after commencing a zinc deficient diet, but after 30 days rose to control values. Under controlled conditions plasma zinc can be used as an indication of zinc deficiency. Whole blood zinc is of no value in the detection of zinc deficiency. Urine zinc concentration varies with time following a zinc deficient diet.
对食用缺锌和补锌饮食共65天的成年幼鼠进行了血浆、全血和尿液锌的系列测量。开始缺锌饮食后，血浆锌在48小时内降至对照值的25%，并在整个研究期间维持在该水平。观察到血浆锌有显著的昼夜变化，禁食状态下水平显著降低。全血锌不受禁食影响，无昼夜变化，即使在缺锌饮食65天后仍维持在对照值。开始缺锌饮食10天后，尿液锌降至极低值，但30天后升至对照值。在受控条件下，血浆锌可作为缺锌的指标。全血锌在检测缺锌方面无价值。缺锌饮食后，尿液锌浓度随时间变化。
