Murano T, Senda H, Yamamoto H, Yano I
Jpn J Pharmacol. 1978 Jun;28(3):403-12. doi: 10.1254/jjp.28.403.
Influence of morphine on the fine structure of mitochondria in the cell of zona fasciculata of adrenal cortex in mice treated chronically with morphine pellets was studied using the electron microscope. The trnasformation of mitochondrial structure was observed 12 hours after morphine pellet implantation and the degree of transformation reached a maximum at 48 hours. These changes, however, disappeared within 4 days. On the 4th day after implantation, removal of the pellet or levallorphan challenge resulted in alteration of the mitochondria with evidence of withdrawal syndrome. Reinjection of morphine to the mice immediately after removal of the pellet, however, prevented the appearance of such mitochondrial transformation. Chlorpromazine or sodium pentobarbital did not affect on the transformation of mitochondria.
采用电子显微镜研究了长期用吗啡丸处理的小鼠肾上腺皮质束状带细胞中吗啡对线粒体精细结构的影响。在植入吗啡丸12小时后观察到线粒体结构的变化，且变化程度在48小时时达到最大。然而，这些变化在4天内消失。在植入后的第4天，取出药丸或用烯丙左吗喃激发会导致线粒体改变，出现戒断综合征的迹象。然而，在取出药丸后立即给小鼠重新注射吗啡可防止这种线粒体转变的出现。氯丙嗪或戊巴比妥钠对线粒体的转变没有影响。
