Gofferje H, Undeutsch K
Z Alternsforsch. 1978;33(2):155-60.
A significant improvement in the protein metabolism of twelve malnourished geriatric patients was achieved during a three-week daily supplement of the hospital diet with 9 g essential amino acids (8 classic essential amino acids plus histidine). This was especially evident in the doubled serum concentration of pre-albumin and retinol-binding-protein which may be regarded as highly sensitive parameters of protein metabolism. There was a significant increase of total protein and hemoglobin into the lowest normal range. The immunoglobulins IgG, IgA and IgM, however, remained unchanged for the entire observation period.
在为期三周的时间里，通过每日在医院饮食中补充9克必需氨基酸（8种经典必需氨基酸加组氨酸），12名营养不良的老年患者的蛋白质代谢有了显著改善。这在血清前白蛋白和视黄醇结合蛋白浓度翻倍的情况中尤为明显，这两种蛋白可被视为蛋白质代谢高度敏感的指标。总蛋白和血红蛋白显著增加至最低正常范围。然而，在整个观察期内，免疫球蛋白IgG、IgA和IgM保持不变。
