Kato H, Velasco M E, Rothchild I
Acta Endocrinol (Copenh). 1978 Nov;89(3):425-31. doi: 10.1530/acta.0.0890425.
Frontal hypothalamic deafferentation (FHD), which disconnects the anterior hypothalamus from the preoptic area, stops the twice daily surges of prolactin secretion of pregnancy or pseudopregnancy in the rat, and causes rapid luteolysis. Medial hypothalamic deafferentation (MHD), which separates the anterior from the posterior half of the hypothalamus, does not interrupt pregnancy and causes a significant increase in the size of the corpora lutea. To see whether MHD induces an increase in the basal level of prolactin secretion and/or a change in the pattern of prolactin surges, pseudopregnant rats were subjected to MHD or a sham operation on day 3 (day 1 = day of oestrus) and their bloods assayed for prolactin on either day 5 or days 7--8. MHD caused a specific disappearance of the day-time prolactin surge and a diminution in the height of the night-time surge, but no change from the controls in the basal prolactin level. In spite of what thus appears to be a lesser secretion of prolactin than in the controls, the corpora lutea of the MHD rats were larger, and progesterone was secreted at a higher rate and for a longer time, than in the controls. The relation of these findings to the existence of a "surge centre" in the hypothalamus was discussed.
额叶下丘脑去传入（FHD），即切断下丘脑前部与视前区的联系，会阻止大鼠在妊娠或假孕期间每日两次的催乳素分泌高峰，并导致快速黄体溶解。内侧下丘脑去传入（MHD），即将下丘脑的前半部分与后半部分分开，不会中断妊娠，且会导致黄体大小显著增加。为了观察MHD是否会导致催乳素分泌基础水平升高和/或催乳素分泌高峰模式改变，在第3天（第1天=发情日）对假孕大鼠进行MHD或假手术，并在第5天或第7 - 8天检测其血液中的催乳素。MHD导致白天催乳素分泌高峰特异性消失，夜间分泌高峰高度降低，但催乳素基础水平与对照组相比无变化。尽管MHD大鼠的催乳素分泌似乎比对照组少，但MHD大鼠的黄体更大，孕酮分泌速率更高且持续时间更长。讨论了这些发现与下丘脑“分泌高峰中心”存在的关系。
