Beliaev V I, Timin E N
Neirofiziologiia. 1976;8(2):161-7. doi: 10.1007/BF01297754.
The minimal concentrations of procaine which block the action potentials of a single Ranvier node were determined under decreased and increased pH in the bathing solution. The changes in concentrations of the basic [B] and cationic [BH+] form of procaine with pH were of monotonic character: [B] drops and [BH+] grows with pH increase. The dependence of membrane excitability (fraction of channels are able to excite) on pH was nonmonotonic; it is low under increased and decreased pH. On the basis of these data the hypothesis that the membrane of the Ranvier node may interact with a definite form of procaine is rejected. T he quantitative analysis shows that the membrane interacts with both the basic and cationic forms of procaine but the efficiency of this interaction is different.
在降低和升高灌流液pH值的情况下，测定了阻断单个郎飞结动作电位的最低普鲁卡因浓度。随着pH值的变化，普鲁卡因的碱性形式[B]和阳离子形式[BH⁺]的浓度呈单调变化：随着pH值升高，[B]下降而[BH⁺]升高。膜兴奋性（能够兴奋的通道比例）对pH值的依赖性是非单调的；在pH值升高和降低时均较低。基于这些数据，郎飞结膜可能与特定形式的普鲁卡因相互作用这一假设被否定。定量分析表明，膜与普鲁卡因的碱性和阳离子形式均相互作用，但这种相互作用的效率不同。
