Okada Y, Streisinger G, Emrich J, Newton J, Tsugita A, Inouye M
Science. 1968 Nov 15;162(3855):807-8. doi: 10.1126/science.162.3855.807.
A pair of frame shift mutations in the lysozyme gene of bacteriophage T4 results in the substitution of a glutamyl-tyrosyl sequence for the asparagine residue that is the penultimate amino-terminal amino acid in the lysozyme of the wild-type strain. One of the mutations has been identified as the insertion of two bases, the other as the insertion of a single base.
噬菌体T4溶菌酶基因中的一对移码突变导致野生型菌株溶菌酶倒数第二个氨基末端氨基酸处的天冬酰胺残基被谷氨酰-酪氨酰序列取代。其中一个突变已被确定为两个碱基的插入,另一个为单个碱基的插入。