Medvedeva T E, Alexandrova G I, Smorodintsev A A
J Virol. 1968 May;2(5):456-60. doi: 10.1128/JVI.2.5.456-460.1968.
The ability of temperature variants of influenza A2 virus to produce plaques in chick embryo kidney tissue culture was studied at different temperatures. Definite differences in efficiency of plaque formation by cryophilic and thermophilic strains were observed at low and high temperatures. Differentiation of the temperature variants appears to reside in a number of genetic markers, designated rct-40, rct-28, and plaque size (S). Virulence of influenza A2 virus, enhanced after prolonged cultivation at high temperature, is probably related to its greater efficiency of plating at 40 C (rct-40(+)), formation of larger plaques at optimal (36 C) and high (40 C) temperatures, and to loss of ability to form plaques at 28 C (rct-28(-)).
在不同温度下研究了甲型流感病毒A2温度变异株在鸡胚肾组织培养中产生蚀斑的能力。在低温和高温下观察到嗜冷株和嗜热株形成蚀斑的效率存在明显差异。温度变异株的分化似乎存在于一些遗传标记中，这些标记被命名为rct - 40、rct - 28和蚀斑大小（S）。甲型流感病毒A2在高温下长时间培养后毒力增强，这可能与其在40℃时更高的接种效率（rct - 40(+)）、在最佳温度（36℃）和高温（40℃）下形成更大的蚀斑以及在28℃时失去形成蚀斑的能力（rct - 28(-)）有关。
