Beck P, Malarkey W B
Am J Obstet Gynecol. 1976 Mar 15;124(6):578-81. doi: 10.1016/0002-9378(76)90058-2.
Serum prolactin concentrations were measured serially in eight normal women who used continuous chlormadinone acetate treatment (500 mug per day) for six months as part of an investigational new drug contraceptive study. Circulating prolactin was also measured in women using several additional oral contraceptive steroid preparations including a sequential mestranol-mestranol + chlormadinone acetate regimen. No increase in basal serum prolactin concentration was produced by chlormadinone acetate treatment, either alone or when added to estrogen therapy. These results suggest that chlormadinone acetate may not alter human mammary tissue through a prolactin mechanism.
在一项研究性新药避孕研究中，对8名正常女性进行连续醋酸氯地孕酮治疗（每天500微克），为期6个月，并连续测量其血清催乳素浓度。还对使用其他几种口服避孕甾体制剂（包括炔雌醇-炔雌醇+醋酸氯地孕酮序贯方案）的女性进行了循环催乳素的测量。单独使用醋酸氯地孕酮治疗或与雌激素联合治疗时，均未导致基础血清催乳素浓度升高。这些结果表明，醋酸氯地孕酮可能不会通过催乳素机制改变人体乳腺组织。
