[前列腺素对胚胎心肌的作用]
[Effect of prostaglandins on embryonal myocardium].
作者信息
Mirzoian S A, Boroian R G
出版信息
Farmakol Toksikol. 1978 Nov-Dec;41(6):683-6.
In tests set up with cultivated isolated cells and explants of the myocardium of 3- and 7-day chicken embryos a positive inotropic and less marked positive chronotropic action of prostaglandins (PG) were disclosed. These effects of PG are fully blocked with polyphloretin phosphate and by addition to the incubation medium of ethylene-glycol-bis (beta-aminoethyl)N,N1-tetraacetate (EGTA), whereas in increased Ca2+ concentration in the nutrient medium potentiates the inotropic effects of PGE1. The data obtained suggest that the cardiostimulating action of PG is realized through the specific prostaglandin-sensitive myocardium receptors.
在用3日龄和7日龄鸡胚心肌的培养分离细胞和外植体进行的试验中，发现前列腺素（PG）具有正性肌力作用以及不太明显的正性变时作用。PG的这些作用可被聚磷酸根皮苷完全阻断，也可通过向孵育培养基中添加乙二醇双（β-氨基乙基）N，N'-四乙酸（EGTA）来阻断，而在营养培养基中增加Ca2+浓度会增强PGE1的正性肌力作用。所获得的数据表明，PG的心脏刺激作用是通过特定的前列腺素敏感心肌受体实现的。
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