外感受性刺激对泌乳大鼠排乳的影响。

The effect of an exteroceptive stimulus on milk ejection in lactating rats.

作者信息

Deis R P

出版信息

J Physiol. 1968 Jul;197(1):37-46. doi: 10.1113/jphysiol.1968.sp008543.

DOI:10.1113/jphysiol.1968.sp008543

PMID:5691944

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1351782/

Abstract

The exteroceptive stimulus emanating from a lactating rat and the litter while suckling was used to induce milk ejection in another lactating mother 15 min before the replacement of her own litter. The effect of the external stimulus on milk ejection during one 30 min period and four 15 min periods of nursing was studied.2. After being isolated for 9 hr the litter from the mother subjected to the exteroceptive nursing stimulus (induced rat) obtained a significantly greater amount of milk during 30 min of nursing than that obtained by the litter from the control mother.3. When deaf mother rats were used the gain of milk by the litter showed no difference between the control and the induced mother. This result indicated that the effective external stimulus is an auditory one and is probably produced by the mother rat and the young while suckling.4. The administration of oxytocin (Syntocinon, Sandoz) 20 m-u./100 g body wt., 15 min before the replacement of the litter produced a milk ejection similar to that obtained under the influence of the auditory stimulus. This would indicate that the exteroceptive stimulus probably evokes the release of oxytocin from the neurohypophysis.5. When nursing was performed in four periods of 15 min each the litter of the control mother obtained milk only in the second period of nursing while the litter of the induced mother obtained milk in all four periods of nursing and the amount of milk obtained in the whole hour was greater than that from the control rat.6. The administration of oxytocin just before the replacement of the litter every 15 min produced milk ejection only in the first two periods of suckling in the control rats but the induced rats were capable of ejecting milk during all four periods.7. The most satisfactory conclusion for the results obtained is that the C.N.S. regulates both the release of oxytocin in response to suckling and the response of the mammary gland to oxytocin, in the lactating rat.

摘要

在替换自己的幼崽前15分钟，用正在哺乳的大鼠及其幼崽发出的外感受性刺激，来诱导另一只正在哺乳的母鼠排乳。研究了外部刺激在一个30分钟哺乳期和四个15分钟哺乳期内对排乳的影响。
接受外感受性哺乳刺激的母鼠（诱导大鼠）的幼崽在隔离9小时后，在30分钟的哺乳期内获得的乳汁量显著多于对照母鼠的幼崽。
当使用失聪的母鼠时，对照母鼠和诱导母鼠的幼崽所获乳汁量没有差异。这一结果表明，有效的外部刺激是听觉刺激，可能由母鼠和幼崽在哺乳时发出。
在替换幼崽前15分钟，按每100克体重注射20毫微克催产素（合成催产素，山德士公司），可产生与听觉刺激影响下相似的排乳效果。这表明外感受性刺激可能促使神经垂体释放催产素。
当哺乳分为四个15分钟的时段进行时，对照母鼠的幼崽仅在第二个哺乳时段获得乳汁，而诱导母鼠的幼崽在所有四个哺乳时段都能获得乳汁，且整个小时内获得的乳汁量多于对照大鼠。
在每次替换幼崽前15分钟注射催产素，对照大鼠仅在前两个哺乳时段出现排乳，但诱导大鼠在所有四个时段都能排乳。
对所获结果最合理的结论是，在哺乳期大鼠中，中枢神经系统既调节因哺乳而产生的催产素释放，也调节乳腺对催产素的反应。