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Metabolic products of microorganisms. 155. Modes of action of rinamycin and derinamycin.

作者信息

Uchida K, Zähner H

出版信息

Arch Microbiol. 1976 Mar 19;107(2):161-6. doi: 10.1007/BF00446835.

DOI:10.1007/BF00446835
PMID:56926
Abstract

Rinamycin interfered with DNA-polymerase I of Escherichia coli in cell-free systems more effectively than actinomycin C. Its inhibitory action could be relieved by increasing the concentration of polymerase. The rinamycin concentrations that caused effective inhibition of the RNA-polymerase reaction in vitro were approximately 10 times higher than those required to inhibit the DNA-polymerase reaction in vitro.

摘要

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本文引用的文献

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The role of deoxyribonucleic acid in ribonucleic acid synthesis. III. The inhibition of the enzymatic synthesis of ribonucleic acid and deoxyribonucleic acid by actinomycin D and proflavin.脱氧核糖核酸在核糖核酸合成中的作用。III. 放线菌素D和原黄素对核糖核酸和脱氧核糖核酸酶促合成的抑制作用。
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Interaction of kanchanomycin with nucleic acids. 3. Contrasts in the mechanisms of inhibition of ribonucleic acid and deoxyribonucleic acid polymerase reactions.坎查霉素与核酸的相互作用。3. 核糖核酸和脱氧核糖核酸聚合酶反应抑制机制的对比。
Biochemistry. 1970 Oct 27;9(22):4421-7. doi: 10.1021/bi00824a025.