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人和小鼠次黄嘌呤-鸟嘌呤磷酸核糖转移酶：二聚体和四聚体。

Human and mouse hypoxanthine-guanine phosphoribosyltransferase: dimers and tetramers.

作者信息

Johnson G G, Eisenberg L R, Migeon B R

出版信息

Science. 1979 Jan 12;203(4376):174-6. doi: 10.1126/science.569362.

DOI:10.1126/science.569362
PMID:569362
Abstract

Human and mouse hypoxanthine-guanine phosphoribosyltransferase subunits combine to form an active heteropolymer. Dimers form the basic subunit structure of the enzymes, yet the dimers can readily associate to form tetramers. The equilibrium between dimers and tetramers is significantly influenced by the ionic strength of the enzyme solvent.

摘要

人和小鼠次黄嘌呤 - 鸟嘌呤磷酸核糖基转移酶亚基结合形成有活性的杂聚物。二聚体构成了该酶的基本亚基结构，但二聚体可轻易缔合形成四聚体。二聚体与四聚体之间的平衡受酶溶剂离子强度的显著影响。

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1
Human and mouse hypoxanthine-guanine phosphoribosyltransferase: dimers and tetramers.人和小鼠次黄嘌呤-鸟嘌呤磷酸核糖转移酶：二聚体和四聚体。
Science. 1979 Jan 12;203(4376):174-6. doi: 10.1126/science.569362.
2
[Chinese hamster cells mutant for the hypoxanthine-guanine phosphoribosyltransferase locus. IV. The biochemical characteristics of the hypoxanthine-guanine phosphoribosyltransferase of hybrid clones obtained by intragenic complementation].[次黄嘌呤-鸟嘌呤磷酸核糖转移酶基因座突变的中国仓鼠细胞。IV. 通过基因内互补获得的杂交克隆的次黄嘌呤-鸟嘌呤磷酸核糖转移酶的生化特性]
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4
Human hypoxanthine-guanine phosphoribosyltransferase. Evidence for tetrameric structure.人次黄嘌呤-鸟嘌呤磷酸核糖基转移酶。四聚体结构的证据。
J Biol Chem. 1978 Jun 25;253(12):4459-63.
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Hypoxanthine-guanine phosphoribosyltransferase in human erythroid cells: properties of the isozymes.人类红细胞中的次黄嘌呤 - 鸟嘌呤磷酸核糖转移酶：同工酶的特性
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Studies of human-mouse cell hybrids with respect to X-chromosome inactivation.
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[Genetic and biochemical study of allele variants of hypoxanthine phosphoribosyltransferase in the house mouse].[家鼠次黄嘌呤磷酸核糖基转移酶等位基因变体的遗传与生化研究]
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Stability of DNA methylation of the human hypoxanthine phosphoribosyltransferase gene.人类次黄嘌呤磷酸核糖转移酶基因DNA甲基化的稳定性
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Inactive X chromosome DNA does not function in DNA-mediated cell transformation for the hypoxanthine phosphoribosyltransferase gene.对于次黄嘌呤磷酸核糖转移酶基因而言，失活的X染色体DNA在DNA介导的细胞转化中不起作用。
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Determination of the subunit molecular weight of hypoxanthine-guanine phosphoribosyltransferase from human erythrocytes by recovery of enzyme activity from sodium dodecyl sulphate gels.通过从十二烷基硫酸钠凝胶中回收酶活性来测定人红细胞次黄嘌呤-鸟嘌呤磷酸核糖基转移酶的亚基分子量
Biochim Biophys Acta. 1975 Dec 18;410(2):426-30. doi: 10.1016/0005-2744(75)90247-8.

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Genetic evidence for the inactivation of a human autosomal locus attached to an inactive X chromosome.与失活X染色体相连的人类常染色体位点失活的遗传学证据。
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Human hypoxanthine-guanine phosphoribosyltransferase. Demonstration of structural variants in lymphoblastoid cells derived from patients with a deficiency of the enzyme.
人次黄嘌呤 - 鸟嘌呤磷酸核糖转移酶。源自该酶缺乏症患者的淋巴母细胞中结构变异体的证明。
J Clin Invest. 1982 Mar;69(3):706-15. doi: 10.1172/jci110499.
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Isolation of a genomic clone partially encoding human hypoxanthine phosphoribosyltransferase.部分编码人次黄嘌呤磷酸核糖基转移酶的基因组克隆的分离
Proc Natl Acad Sci U S A. 1982 Aug;79(16):5038-41. doi: 10.1073/pnas.79.16.5038.
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Partial purification and characterization of the mRNA for human thymidine kinase and hypoxanthine/guanine phosphoribosyltransferase.人胸苷激酶和次黄嘌呤/鸟嘌呤磷酸核糖转移酶mRNA的部分纯化及特性分析
Proc Natl Acad Sci U S A. 1982 Jul;79(14):4290-4. doi: 10.1073/pnas.79.14.4290.
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Hypoxanthine-guanine phosphoribosyltransferase in human erythroid cells: properties of the isozymes.人类红细胞中的次黄嘌呤 - 鸟嘌呤磷酸核糖转移酶：同工酶的特性
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Proc Natl Acad Sci U S A. 1983 Aug;80(15):4709-13. doi: 10.1073/pnas.80.15.4709.
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