人和小鼠次黄嘌呤-鸟嘌呤磷酸核糖转移酶：二聚体和四聚体。
Human and mouse hypoxanthine-guanine phosphoribosyltransferase: dimers and tetramers.
作者信息
Johnson G G, Eisenberg L R, Migeon B R
出版信息
Science. 1979 Jan 12;203(4376):174-6. doi: 10.1126/science.569362.
PMID:569362
Abstract
Human and mouse hypoxanthine-guanine phosphoribosyltransferase subunits combine to form an active heteropolymer. Dimers form the basic subunit structure of the enzymes, yet the dimers can readily associate to form tetramers. The equilibrium between dimers and tetramers is significantly influenced by the ionic strength of the enzyme solvent.
摘要
人和小鼠次黄嘌呤 - 鸟嘌呤磷酸核糖基转移酶亚基结合形成有活性的杂聚物。二聚体构成了该酶的基本亚基结构，但二聚体可轻易缔合形成四聚体。二聚体与四聚体之间的平衡受酶溶剂离子强度的显著影响。
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