原发性“获得性”低丙种球蛋白血症与淀粉样变性
Primary "acquired" hypogammaglobulinaemia and amyloidosis.
作者信息
Murray W D, Cook I A
出版信息
J Clin Pathol. 1968 Jan;21(1):32-4. doi: 10.1136/jcp.21.1.32.
Abstract
The clinical details and post-mortem findings are given of a patient who had primary ;acquired' hypogammaglobulinaemia and was found at necropsy to have amyloidosis. The relationship of gamma globulin deficiency to amyloidosis is discussed, and the possible relevance of the hypogammaglobulinaemia to the formation and nature of amyloid is noted. It is suggested that a disordered immune response may be an essential prerequisite for the development of amyloidosis.
摘要
本文给出了一名原发性“获得性”低丙种球蛋白血症患者的临床细节及尸检结果，该患者尸检时被发现患有淀粉样变性。文中讨论了丙种球蛋白缺乏与淀粉样变性的关系，并指出低丙种球蛋白血症与淀粉样蛋白的形成及性质可能存在关联。研究表明，免疫反应紊乱可能是淀粉样变性发生发展的必要前提条件。
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