Davey M G, Lander H
J Clin Pathol. 1968 Jan;21(1):55-9. doi: 10.1136/jcp.21.1.55.
Platelets from six normal subjects were labelled with radiochromate and reinfused into their donors. Subsequently, the effect of intravenously injected heparin upon the levels of circulating platelets and platelet radioactivity was studied. Although reductions in platelet counts occurred in three subjects following single injections of 10,000 units, these changes were not reflected in the levels of circulating platelet radioactivity. It is concluded that the alterations in platelet counts observed were probably due to an effect of heparin in vitro. The experimental evidence that heparin induces thrombocytopenia in vivo, in man, is unconvincing.
从六名正常受试者采集的血小板用放射性铬酸盐标记后回输给供血者。随后，研究了静脉注射肝素对循环血小板水平和血小板放射性的影响。尽管在单次注射10,000单位肝素后，三名受试者的血小板计数出现了下降，但这些变化并未反映在循环血小板放射性水平上。得出的结论是，观察到的血小板计数变化可能是由于肝素在体外的作用。肝素在人体内可诱导血小板减少症的实验证据并不令人信服。
