Fell G S, Smith H, Howie R A
J Clin Pathol. 1968 Jan;21(1):8-11. doi: 10.1136/jcp.21.1.8.
A method for the neutron activation analysis of copper in biological material is described and applied to the diagnosis and management of four cases of Wilson's disease. Results obtained for serum and urine are in agreement with values obtained by established colorimetric techniques. The method described can estimate 10(-9) g. copper to within 10% and this sensitivity has allowed the determination of copper from biopsy material such as liver, spleen, hair, and nail.
本文描述了一种用于生物材料中铜的中子活化分析方法，并将其应用于4例威尔逊病的诊断和治疗。血清和尿液的检测结果与既定比色技术所获值一致。所述方法可将铜含量估计至10⁻⁹ g，误差在10%以内，这种灵敏度使得能够测定来自肝脏、脾脏、毛发和指甲等活检材料中的铜含量。
