Shirama K
Neuroendocrinology. 1978;27(5-6):193-203. doi: 10.1159/000122812.
The effect of constant light on the age at onset of persistent estrus was compared in rats exposed to constant light since birth (LL-0) and those exposed beginning at 70 days of age (LL-70). Persistent estrus occurred about 27 days later in the LL-0 rats than in the LL-70 rats. Exposure to LL for just the 1st 15 days of life (LL-0-15) and then subsequent exposure to LL at 71 days also delayed the induction of persistent estrus. Neonatal injection of a Harderian gland (HG) homogenate to LL-0-15 rats reduced the age of vaginal opening and 1st estrus and reduced the delayed onset of persistent estrus caused by the neonatal LL. Harderianectomy of LL-0 or hematoporphyrin injections in LL-0-15 rats had no effect on the onset of LL-induced persistent estrus.
比较了自出生起就暴露于持续光照下的大鼠（LL-0）和70日龄开始暴露于持续光照下的大鼠（LL-70），持续光照对持续性发情起始年龄的影响。LL-0大鼠出现持续性发情的时间比LL-70大鼠晚约27天。仅在出生后的前15天暴露于持续光照下（LL-0-15），然后在71天再次暴露于持续光照下，也会延迟持续性发情的诱导。给LL-0-15大鼠新生期注射哈德氏腺（HG）匀浆，可降低阴道开口和首次发情的年龄，并减少新生期持续光照导致的持续性发情延迟起始。对LL-0大鼠进行哈德氏腺切除或给LL-0-15大鼠注射血卟啉，对持续光照诱导的持续性发情起始没有影响。
