左心房感受器在左心房扩张利尿反应中的作用。

The role of left atrial receptors in th diuretic response to left atrial distension.

作者信息

Ledsome J R, Linden R J

出版信息

J Physiol. 1968 Sep;198(2):487-503. doi: 10.1113/jphysiol.1968.sp008619.

DOI:10.1113/jphysiol.1968.sp008619

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1365336/

Abstract

The diuretic response to distension of the whole left atrium caused by obstruction of the mitral orifice has been compared with the effects of distension (by means of small balloons) of the left pulmonary vein/left atrial junctions.2. Distension of the pulmonary vein/atrial junctions caused an increase in heart rate and a diuresis similar to but smaller than that caused by mitral obstruction.3. Section of both ansae subclaviae prevented the increase in heart rate produced by distension of the pulmonary vein/left atrial junctions but had little effect on the diuretic response either to pulmonary vein distension or to mitral obstruction.4. A diuretic response to mitral obstruction could be demonstrated after all nerves from the lungs had been cut but not after the vagus nerves had been cut at levels likely to interrupt the majority of afferent fibres from left atrial receptors.5. The results support the view that stimulation of left atrial receptors is a major factor in the production of a diuretic response to mitral obstruction.

摘要

已将二尖瓣口梗阻所致整个左心房扩张引起的利尿反应与左肺静脉/左心房交界处扩张（通过小气球）的效果进行了比较。
肺静脉/心房交界处的扩张引起心率加快和利尿，与二尖瓣梗阻引起的相似但程度较小。
切断双侧锁骨下袢可防止肺静脉/左心房交界处扩张引起的心率加快，但对肺静脉扩张或二尖瓣梗阻引起的利尿反应影响很小。
在切断来自肺部的所有神经后，仍可证明对二尖瓣梗阻有利尿反应，但在可能中断来自左心房感受器的大多数传入纤维的水平切断迷走神经后则无此反应。
这些结果支持这样一种观点，即刺激左心房感受器是对二尖瓣梗阻产生利尿反应的主要因素。