乙醇喂养对大鼠骨骼成分的影响。

Effect of ethanol feeding on bone composition in the rat.

作者信息

Mezey E, Potter J J, Merchant C R

出版信息

Am J Clin Nutr. 1979 Jan;32(1):25-9. doi: 10.1093/ajcn/32.1.25.

DOI:10.1093/ajcn/32.1.25

Abstract

The effect of ethanol feeding for a period of 3 months on the mineral and collagen content of bone was determined in the rat. Ethanol feeding resulted in no changes in the density or in the concentrations of calcium, phosphorus, hydroxyproline, or nitrogen in the tibiae. Also, the serum concentrations of calcium, phosphorus, and 25-hydroxyvitamin D were unaffected by ethanol feeding. The development of a mild degree of osteomolacia was suggested, however, by decreases in EDTA-extractable mineral content and in the calcium/hydroxyproline ratio in the tibiae of the ethanol-fed as compared with the control animals. The urinary excretion of glycosaminoglycans was not changed by ethanol-feeding while the urinary excretion of peptide-bound hydroxyproline was increased. The minimal bone changes found after ethanol feeding in this study are an unlikely cause for the observed increases in the urinary excretion of hydroxyproline.

摘要

在大鼠中测定了为期3个月的乙醇喂养对骨骼矿物质和胶原蛋白含量的影响。乙醇喂养并未导致胫骨密度、钙、磷、羟脯氨酸或氮浓度的变化。此外，乙醇喂养对血清钙、磷和25-羟基维生素D的浓度没有影响。然而，与对照动物相比，乙醇喂养大鼠胫骨中可被乙二胺四乙酸（EDTA）提取的矿物质含量以及钙/羟脯氨酸比值降低，提示出现了轻度骨软化症。乙醇喂养并未改变糖胺聚糖的尿排泄量，而肽结合羟脯氨酸的尿排泄量增加。本研究中乙醇喂养后发现的轻微骨骼变化不太可能是观察到的羟脯氨酸尿排泄增加的原因。