Lian E C, Harkness D R, Byrnes J J, Wallach H, Nunez R
Blood. 1979 Feb;53(2):333-8.
Three patients with thrombotic thrombocytopenic purpura (TTP) were treated by infusion of normal plasma with dramatic responses. The plasmas collected from these patients during relapse induced in vitro aggregation of washed platelets from both normal donors and the patients during remission. The platelet aggregating factor was not dialyzable or adsorbable by Al(OH)3 and was not inactivated by diisopropylfluorophosphate, hirudin, or heparin in the presence of normal amounts of antithrombin. In contrast to the platelet aggregation induced by platelet isoantibody, the platelet aggregating activity of TTP plasma diminished as a function of time when it was incubated with normal plasma at 37 degrees C. These observations suggest that at least some instances of TTP appear to be due to deficiency of a plasma inhibitor to counteract a platelet aggregating factor demonstrated to be present in the plasma of these patients.
三名血栓性血小板减少性紫癜（TTP）患者通过输注正常血浆进行治疗，效果显著。从这些患者复发期间采集的血浆在体外可诱导正常供体以及缓解期患者的洗涤血小板聚集。血小板聚集因子不能被透析，也不能被氢氧化铝吸附，在正常量抗凝血酶存在的情况下，不会被异丙基氟磷酸酯、水蛭素或肝素灭活。与血小板同种抗体诱导的血小板聚集不同，TTP血浆的血小板聚集活性在37℃与正常血浆孵育时会随时间而降低。这些观察结果表明，至少某些TTP病例似乎是由于血浆中缺乏一种抑制剂来对抗已证实在这些患者血浆中存在的血小板聚集因子。
