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在诱导增殖的肝脏和肾脏中,刺激的DNA合成与胸苷和胸苷酸激酶活性未改变相关。

Stimulated DNA synthesis in livers and kidneys induced to proliferate associated with unchanged thymidine and thymidylate kinase activities.

作者信息

Cihák A, Seifertová M

出版信息

Chem Biol Interact. 1976 May;13(2):141-9. doi: 10.1016/0009-2797(76)90003-x.

DOI:10.1016/0009-2797(76)90003-x
PMID:57007
Abstract

Enhanced mitotic activity and stimulated DNA synthesis associated with unchanged activity of thymidine and thymidylate kinases were observed in mouse kidneys induced to proliferate by intracardiac injection of lead acetate, and in rat livers following repeated administration of 5-azacytidine. On the other hand, the enhanced thymidine kinase activity evoked by L-tryptophan given by intubation at later stages of liver regeneration was paralleled by the enhanced incorporation of thymidine into DNA only to a very small degree.

摘要

在心内注射醋酸铅诱导增殖的小鼠肾脏以及反复给予5-氮杂胞苷后的大鼠肝脏中,观察到有丝分裂活性增强和DNA合成受刺激,而胸苷激酶和胸苷酸激酶的活性未改变。另一方面,在肝再生后期经插管给予L-色氨酸所引起的胸苷激酶活性增强,与之平行的是胸苷掺入DNA的增加,但程度非常小。

相似文献

1
Stimulated DNA synthesis in livers and kidneys induced to proliferate associated with unchanged thymidine and thymidylate kinase activities.在诱导增殖的肝脏和肾脏中,刺激的DNA合成与胸苷和胸苷酸激酶活性未改变相关。
Chem Biol Interact. 1976 May;13(2):141-9. doi: 10.1016/0009-2797(76)90003-x.
2
Enhanced incorporation of thymidine into DNA in the liver of intact and partially hepatectomized rats pretreated with 5-azacytidine.用5-氮杂胞苷预处理的完整和部分肝切除大鼠肝脏中,胸腺嘧啶核苷掺入DNA的量增加。
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Metabolic alterations of liver regeneration. XV. Cadmium-mediated depression of thymidine and thymidylate kinase induction in rats.肝脏再生的代谢变化。十五。镉介导的大鼠胸腺嘧啶核苷和胸苷酸激酶诱导的抑制作用。
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[Fate of thymidine and thymidylate kinases during cell cycle in KB cells. Influence of the synchronization method on activity].[KB细胞周期中胸苷和胸苷酸激酶的命运。同步化方法对活性的影响]
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[The effect of cortisone on cell division and thymidine-and thymidylate-kinase activity in regenerating rat liver].[可的松对再生大鼠肝脏细胞分裂及胸苷和胸苷酸激酶活性的影响]
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The effect of urethan on the incorporation of thymidine-3H into DNA and the activities of some enzymes required for DNA biosynthesis in rat regenerating liver.乌拉坦对大鼠再生肝中胸腺嘧啶核苷-3H掺入DNA以及DNA生物合成所需某些酶活性的影响。
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[The effect of cortisone on the activity of thymidine- and thymidylate-kinases isolated from regenerating rat liver].[可的松对从再生大鼠肝脏中分离出的胸苷激酶和胸苷酸激酶活性的影响]
Vopr Med Khim. 1967 Jul-Aug;13(4):432-3.

引用本文的文献

1
L-Tryptophan action on hepatic RNA synthesis and enzyme induction.L-色氨酸对肝脏RNA合成及酶诱导的作用。
Mol Cell Biochem. 1979 Apr 2;24(3):131-42. doi: 10.1007/BF00220732.