Haeger-Aronsen B, Krook G, Abdulla M
Int J Dermatol. 1979 Jan-Feb;18(1):73-82. doi: 10.1111/j.1365-4362.1979.tb01920.x.
beta-Carotene and canthaxanthin in a dose of 75--250 mg a day by mouth reduced the symptons of exposure to the sun in all 7 treated patients with erythrohepatic protoporphyria (EPP), in 15 of 18 with polymorphous light eruptions (PMLE) and in 3 of 4 with lupus erythematodes discoides. In the EPP group the protoporphyrin level tended to vary inversely with that of the serum carotenoids. The level of retinol-binding protein in plasma remained unchanged despite a substantial rise in the concentration of the serum carotenoids. Estimation of the minimal erythema dose for unfiltered light from a Xenon lamp in 7 patients with PMLE showed an increase in only 1 patient. Neither clinical examination nor repeated laboratory studies revealed any serious side effects of the treatment.
每天口服75 - 250毫克的β-胡萝卜素和角黄素，可减轻所有7例患有红细胞生成性原卟啉症（EPP）的患者、18例多形性日光疹（PMLE）患者中的15例以及4例盘状红斑狼疮患者中的3例的晒伤症状。在EPP组中，原卟啉水平往往与血清类胡萝卜素水平呈负相关。尽管血清类胡萝卜素浓度大幅上升，但血浆中视黄醇结合蛋白水平保持不变。对7例PMLE患者进行的未过滤氙灯最小红斑量估计显示，只有1例患者的最小红斑量增加。临床检查和重复的实验室研究均未发现该治疗有任何严重副作用。
