Luthman J, Jonson G
Acta Vet Scand. 1968;9(2):168-73. doi: 10.1186/BF03547881.
When butyric acid was injected intravenously at an amount of 2.5 mM/kg, blood glucose rose markedly in normal sheep. In a ewe with pregnancy toxemia blood glucose did not change. When the same amount was injected intraruminally to sheep and cows, the plasma level of non-esterified fatty acids, NEFA, was in most cases decreased by about 30—50 %, while blood glucose remained almost unchanged. The same results were obtained when the double amount, 5 mM/kg, was used. The depressant effect of butyric acid on NEFA after intravenous and intraruminal administration is discussed. When butyrate occurs in the circulating blood a breakdown of liver glycogen is induced and the resulting hyperglycemia causes a decrease in the NEFA level. The butyric acid which is infused into or produced in the rumen is probably completely metabolized to ketone bodies in the rumen epithelium and depresses NEFA indirectly by increasing the production of insulin.
当以2.5 mM/kg的剂量静脉注射丁酸时，正常绵羊的血糖显著升高。而在患有妊娠毒血症的母羊中，血糖没有变化。当以相同剂量向绵羊和奶牛瘤胃内注射时，大多数情况下，非酯化脂肪酸（NEFA）的血浆水平下降了约30% - 50%，而血糖几乎保持不变。使用双倍剂量5 mM/kg时也得到了相同的结果。本文讨论了静脉注射和瘤胃内注射丁酸后对NEFA的抑制作用。当丁酸出现在循环血液中时，会诱导肝糖原分解，由此产生的高血糖会导致NEFA水平下降。注入瘤胃或在瘤胃中产生的丁酸可能在瘤胃上皮中完全代谢为酮体，并通过增加胰岛素的分泌间接降低NEFA水平。
